What are the Causes of Peyronie’s Disease

The exact causes of Peyronie’s disease are unclear. But many researchers have thought that minor trauma during  sexual intercourse or repeated bending or bumping of the erect penis leads to minor tears in the tunica  or rupture of the blood vessels inside the penis.

During bleeding and abnormal healing process, the scar tissue forms in the lining of the “tunica albuginea” or  the erectile tissue that causes to microscopic injury to the penis.

If left untreated, a penile trauma may cause scarring at the site of the rupture that causes subsequent curvature of the penis during erection.

Keep in mind, the plaque that builds inside the penis is not the same plaque that can be found in a person’s arteries.

Other possible causes of Peyronie’s disease are:

  • Genetic factor with a condition called Dupuytren’s contracture of the hands
  • Autoimmune reaction forming “antielastin antibodies” attacking its own tissue
  • Penis injury or trauma during sex or vigorous masturbation, physical activity, and accident that occur repeatedly overtime resulting  in a plaque of collagen
  • Abnormal growth of the spongy tissue of the penis
  • Medications that cause Peyronie’s disease:
    • Beta-blockers – prescribed for people with hypertension or heart failure
    • Dilantin – an anti-seizure drug
    • Interferon – prescribed for multiple sclerosis
  • Low level of testosterone

causes of peyronies dieseaseImage: Perito Urology

Who Is More Likely To Get Peyronie’s Disease?

Peyronie’s disease is thought to affect about 3-6% of men between the ages of 40-70 years old. The disease is more common in caucasian men and less common in African and asian men.

It starts to manifest in men in their fifties, but a small number of younger men after puberty also develop the disease.

Other factors may increase the risk of developing Peyronie’s disease include:

  • Aging
  • Obesity
  • Hereditary or family history of Peyronie’s disease
  • Smoking
  • Longer duration and increased severity of ED
  • Diabetes or high blood sugar
  • Past history of pelvic trauma
  • Autoimmune disorders




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